{"id":322,"date":"2017-05-21T13:27:22","date_gmt":"2017-05-21T04:27:22","guid":{"rendered":"http:\/\/medi-information.com\/?p=322"},"modified":"2017-06-10T00:32:58","modified_gmt":"2017-06-09T15:32:58","slug":"post-322","status":"publish","type":"post","link":"https:\/\/medi-information.com\/?p=322","title":{"rendered":"\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8840\u7cd6\u5024\u4f4e\u4e0b\u306e\u4ed5\u7d44\u307f"},"content":{"rendered":"

\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8840\u7cd6\u5024\u4f4e\u4e0b\u306e\u4ed5\u7d44\u307f<\/h2>\n

\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u30db\u30eb\u30e2\u30f3\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002
\n\u3053\u3053\u3067\u306f\u3001\u7d30\u80de\u5185\u3078\u306e\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u304b\u3089\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u653e\u51fa\u3055\u308c\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u307e\u3067\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u8aac\u3057\u3066\u3044\u304f\u3002<\/p>\n

GLUT2\u3068GLUT4<\/h2>\n

\u307e\u305a\u306f\u4e88\u5099\u77e5\u8b58\u3068\u3057\u3066\u8f38\u9001\u62c5\u4f53\u300cGLUT2<\/span><\/span>\u30fbGLUT4<\/span><\/span>\u300d\u306e\u50cd\u304d\u306b\u3064\u3044\u3066\u78ba\u8a8d\u3059\u308b\u3002<\/p>\n

\nPOINT<\/span>
\n\u30fbGLUT2
\n\u5206\u5e03\uff1a\u81b5\u81d3\u03b2\u7d30\u80de\u30fb\u809d\u7d30\u80de
\n\u6a5f\u80fd\uff1a\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u7684\uff09
\n\u30fbGLUT4
\n\u5206\u5e03\uff1a\u7b4b\u7d30\u80de\u30fb\u8102\u80aa\u7d30\u80de
\n\u6a5f\u80fd\uff1a\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u7684\uff09<\/span><\/div>\n

GLUT2\u306f\u81b5\u81d3\u306e\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u5cf6\u03b2\u7d30\u80de\u3084\u809d\u7d30\u80de<\/span><\/span>\u306b\u5b58\u5728\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u7684<\/span><\/span>\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u88dc\u52a9\u3092\u53d7\u3051\u305a\uff09\u306b\u8840\u4e2d\u306e\u7cd6\u3092\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u3080\u3002
\nGLUT4\u306f\u7b4b\u7d30\u80de\u3084\u8102\u80aa\u7d44\u7e54<\/span><\/span>\u306b\u5b58\u5728\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u7684<\/span><\/span>\u306b\u8840\u4e2d\u306e\u7cd6\u3092\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u3080\u3002
\n\u306a\u304a\u3001\uff08\u4e0b\u306b\u8a73\u3057\u304f\u8a18\u8f09\u3057\u3066\u3044\u308b\u304c\uff09GLUT2\u3068GLUT4\u306e\u95a2\u4fc2\u306f\u300cGLUT2\u304b\u3089\u306e\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u306b\u3088\u3063\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u5206\u6ccc\u3055\u308c\u3001\u305d\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u523a\u6fc0\u3092\u53d7\u3051\u3066GLUT4\u306f\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u3092\u884c\u3046<\/span><\/span>\u300d\u3068\u3044\u3063\u305f\u611f\u3058\u3067\u3042\u308b\u3002<\/p>\n

\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u5206\u6ccc\u3055\u308c\u308b\u307e\u3067<\/h2>\n
\n\u6d41\u308c<\/span>
\n\u2460 \u7cd6\u304c\u904e\u5270
\n\u2192 GLUT2\u304b\u3089\u7d30\u80de\u5185\u306b\u7cd6\u304c\u6d41\u5165
\n\u2461 \u7cd6\u304c\u4ee3\u8b1d\u3055\u308c\u308b
\n\u2192 ATP\u304c\u7523\u751f
\n\u2462 ATP\u306b\u3088\u308aK+<\/span>\u30c1\u30e3\u30cd\u30eb\u304c\u9589\u9396
\n\u2192 \u7d30\u80de\u819c\u304c\u8131\u5206\u6975
\n\u2463 Ca2+<\/span>\u30c1\u30e3\u30cd\u30eb\u304c\u958b\u53e3
\n\u2192 Ca2+<\/span>\u304c\u7d30\u80de\u5185\u306b\u6d41\u5165
\n\u2464 \u5206\u6ccc\u9846\u7c92\u5185\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u8840\u4e2d\u3078\u653e\u51fa<\/span><\/div>\n

\u98df\u4e8b\u306a\u3069\u306b\u3088\u308a\u8840\u4e2d\u306e\u7cd6\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001GLUT2\uff08\u8f38\u9001\u62c5\u4f53\uff09\u3092\u4ecb\u3057\u3066\u81b5\u81d3\u306e\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u5cf6\u03b2\u7d30\u80de\u5185\u306b\u7cd6\u304c\u6d41\u5165<\/span><\/span>\u3059\u308b\u3002
\n\u03b2\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u7cd6\u306f\u3001\u4ee3\u8b1d\u7d4c\u8def\uff08TCA\u56de\u8def\u30fb\u89e3\u7cd6\u7cfb\u306a\u3069\uff09\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u3001\u3053\u306e\u6642\u306bATP<\/span><\/span>\u3068\u547c\u3070\u308c\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u304c\u751f\u6210\u3055\u308c\u308b\u3002
\nATP\u306f\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\uff08K+<\/span>\u30c1\u30e3\u30cd\u30eb\uff09\u3092\u9589\u9396\u3059\u308b\u305f\u3081\u3001\uff08\u901a\u5e38\u306fK+<\/span>\u30c1\u30e3\u30cd\u30eb\u306b\u3088\u3063\u3066\u7d30\u80de\u5916\u306b\u6d41\u51fa\u3055\u308c\u3066\u3044\u308b\u306f\u305a\u306e\uff09K+<\/span>\u304c\u7d30\u80de\u5185\u306b\u84c4\u7a4d\u3057\u3066\u3001\u7d30\u80de\u5185\u304c\u6b63\u306b\u5e2f\u96fb\u3059\u308b\u3002
\n\u305d\u306e\u7d50\u679c\u3001\u7d30\u80de\u819c\u306e\u8131\u5206\u6975\u304c\u8d77\u3053\u308a\u305d\u308c\u304c\u5f15\u304d\u91d1\u3068\u306a\u3063\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\uff08Ca2+<\/span>\u30c1\u30e3\u30cd\u30eb\uff09\u304c\u958b\u53e3<\/span><\/span>\u3059\u308b\u3002
\n\u958b\u53e3\u3057\u305fCa2+<\/span>\u30c1\u30e3\u30cd\u30eb\u3092\u4ecb\u3057\u3066\u7d30\u80de\u5185\u306bCa2+<\/span>\u304c\u6d41\u5165\u3057\u3001\u305d\u306e\u523a\u6fc0\u306b\u3088\u3063\u3066\u5206\u6ccc\u9846\u7c92\u5185\u306b\u5b58\u5728\u3059\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u8840\u4e2d\u3078\u653e\u51fa<\/span><\/span>\u3055\u308c\u308b\u3002<\/p>\n

\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u8840\u7cd6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u307e\u3067\uff08\u7b4b\u8089\u30fb\u8102\u80aa\u7d44\u7e54\uff09<\/h2>\n

\u6b21\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u8840\u4e2d\u306b\u653e\u51fa\u3055\u308c\u3066\u304b\u3089\u5b9f\u969b\u306b\u8840\u7cd6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u307e\u3067\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u78ba\u8a8d\u3057\u3066\u3044\u304f\u3002<\/p>\n

\n\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8840\u7cd6\u4f4e\u4e0b<\/span>
\n\u2460 \u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u306b\u7d50\u5408
\n\u2192 \u53d7\u5bb9\u4f53\u306f\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b
\n\u2461 \u53d7\u5bb9\u4f53\u306e\u30ea\u30f3\u9178\u5316\u306b\u523a\u6fc0\u3055\u308c\u9023\u7d9a\u7684\u306b\u30ea\u30f3\u9178\u5316\u304c\u8d77\u3053\u308b
\n\u2462 GLUT4\u304c\u7d30\u80de\u819c\u4e0a\u306b\u79fb\u52d5
\n\u2192 \u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u304c\u4fc3\u9032\u3055\u308c\u308b<\/span><\/div>\n

\u8840\u4e2d\u306b\u653e\u51fa\u3055\u308c\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53<\/span><\/span>\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u53d7\u3051\u6b62\u3081\u308b\u5bb9\u5668\u306e\u3088\u3046\u306a\u3082\u306e\uff09\u306b\u7d50\u5408\u3057\u3066\u3053\u308c\u3092\u30ea\u30f3\u9178\u5316\u3055\u305b\u308b\u3002\u30ea\u30f3\u9178\u5316\u3057\u305f\u53d7\u5bb9\u4f53\u306f\u6d3b\u6027\u5316\u3057\u3066\u7d30\u80de\u5185\u306b\u5b58\u5728\u3059\u308b\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9023\u7d9a\u7684\u306b\u30ea\u30f3\u9178\u5316<\/span><\/span>\u3055\u305b\u3001\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u6700\u7d42\u7684\u306b\u300cGLUT4\u306e\u7d30\u80de\u819c\u4e0a\u3078\u306e\u79fb\u52d5<\/span><\/span>\u300d\u3092\u4fc3\u9032\u3059\u308b\u3002GLUT4\u306f\u30b0\u30eb\u30b3\u30fc\u30b9\uff08\u7cd6\uff09\u306e\u53d6\u308a\u8fbc\u307f\u4f5c\u7528\u304c\u3042\u308b\u305f\u3081\u3001\u8840\u4e2d\u304b\u3089\u7d30\u80de\u5185\u3078\u306e\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u304c\u4fc3\u9032\u3055\u308c\u8840\u7cd6\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/p>\n

\uff0a\u30d7\u30e9\u30b9\u306e\u77e5\u8b58\uff0a
\n\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u306e\u30ea\u30f3\u9178\u5316\u30b7\u30b0\u30ca\u30eb\u306f\u3001GLUT4\u306e\u79fb\u52d5\u3060\u3051\u3067\u306a\u304f\u300c\u9175\u7d20\u306e\u6d3b\u6027\u8abf\u7bc0\u300d\u3084\u300c\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u300d\u306a\u3069\u306b\u3082\u95a2\u308f\u3063\u3066\u3044\u308b\u3002
\n\u30ea\u30f3\u9178\u5316\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308a\u9175\u7d20\u306e\u6d3b\u6027\u304c\u4fc3\u9032\uff08\u307e\u305f\u306f\u6291\u5236\uff09\u3055\u308c\u308b\u3068\u3001\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u5408\u6210\u30fb\u8102\u80aa\u5408\u6210\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306a\u3069\u304c\u4fc3\u9032\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u7cd6\u65b0\u751f\u306f\u6291\u5236\u3055\u308c\u308b\u3002
\n\u30ea\u30f3\u9178\u5316\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308amRNA\u306e\u5408\u6210\u304c\u4fc3\u9032\u3055\u308c\u308b\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u304c\u4fc3\u9032\u3001DNA\u5408\u6210\u304c\u4fc3\u9032\u3055\u308c\u308b\u3068\u7d30\u80de\u5897\u6b96\u304c\u76db\u3093\u306b\u306a\u308a\u6210\u9577\u4f5c\u7528\u304c\u898b\u3089\u308c\u308b\u3002<\/div>\n","protected":false},"excerpt":{"rendered":"

\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8840\u7cd6\u5024\u4f4e\u4e0b\u306e\u4ed5\u7d44\u307f \u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u30db\u30eb\u30e2\u30f3\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u3002 \u3053\u3053\u3067\u306f\u3001\u7d30\u80de\u5185\u3078\u306e\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u304b\u3089\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u653e\u51fa\u3055\u308c\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u307e\u3067\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u8aac\u3057\u3066\u3044\u304f\u3002 GLUT2\u3068GL […]<\/p>\n","protected":false},"author":1,"featured_media":324,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":""},"categories":[11,10],"tags":[],"_links":{"self":[{"href":"https:\/\/medi-information.com\/index.php?rest_route=\/wp\/v2\/posts\/322"}],"collection":[{"href":"https:\/\/medi-information.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medi-information.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medi-information.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medi-information.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=322"}],"version-history":[{"count":19,"href":"https:\/\/medi-information.com\/index.php?rest_route=\/wp\/v2\/posts\/322\/revisions"}],"predecessor-version":[{"id":384,"href":"https:\/\/medi-information.com\/index.php?rest_route=\/wp\/v2\/posts\/322\/revisions\/384"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medi-information.com\/index.php?rest_route=\/wp\/v2\/media\/324"}],"wp:attachment":[{"href":"https:\/\/medi-information.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medi-information.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medi-information.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}